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This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold.
There has been little understanding of acidification functionality in wound healing, highlighting the need to study the efficacy of wound acidification on wound closure and cellular activity in non-infected wounds. This study is focused on establishing the healing potential of wound acidification in non-infected wounds. Acidic buffers, constituting either phosphoric or citric acid, were employed to modify the physiological pH of non-infected full-thickness excisional murine wounds. Acidification of the wound by acidic buffers was found to be an effective strategy to improve wound healing.
Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix
Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor stroma. We previously reported that during angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type I collagen.
Angiogenesis, the development of blood vessels from the pre-existing vasculature, is a key component of embryogenesis and tissue regeneration. Angiogenesis also drives pathologies such as tumor growth and metastasis, and hemangioma development in newborns. On the other hand, promotion of angiogenesis is needed in tissues with vascular insufficiencies, and in bioengineering, to endow tissue substitutes with appropriate microvasculatures. Therefore, much research has focused on defining mechanisms of angiogenesis, and identifying pro- and anti-angiogenic molecules.
Bridge-enhanced ACL repair (BEAR) is a new FDA-approved procedure that allows a torn ACL to heal itself and does not require graft tissue to be taken from another part of the body. Duke Health is one of the few centers in the U.S. to offer the BEAR procedure.
The contemporary literature suggests that a primary feature of recurrence of rotator cuff tear after arthroscopic repair is failure of tendon healing, which can occur for multiple reasons, including compromised tissue quality. Recently, the use of augmentation implants, grafts, or scaffolds has emerged as a strategy to address the issue of deficient rotator cuff tissue. A resorbable bio-inductive collagen implant (REGENETEN; Smith & Nephew, Andover, MA) has been shown to increase tendon thickness when applied in rotator cuff repair. This article presents an experienced surgeon’s tips for implanting this device. In addition, we review the current literature about this bio-inductive implant.
Collagen – probably, one of the most available proteins in our tissues, plays a very important role in structural integrity and tissue regeneration in our human body. Surgical-grade collagen has quite a lot of applications in the healthcare, medical, and pharmaceutical sectors and is making huge advancements in biotechnology and pharmaceutical research. This article aims to investigate the properties, uses, and important contributions of surgical-grade collagen.
Seeking out reliable, certified, contract-based manufacturing for pharmaceutical needs can offer numerous advantages to pharmaceutical companies. The following post contains a list of advantages that are to be considered in favor of outsourcing a contract-based manufacturing medical company for your pharmaceutical needs.
A Glimpse into Strukmyer: an FDA-Approved, ISO-Certified Contract-Based Pharmaceutical Manufacturing Company in the USA
Contract-based pharmaceutical manufacturing companies play a pivotal role in bringing innovative medical solutions to the healthcare and pharmaceutical market. Among these companies, there stands a distinguished organization - Strukmyer. An FDA-approved and ISO-certified, medical manufacturing company based in the USA with a diverse portfolio ranging from surgical collagen to medical devices, medical adhesives, cosmetics, wound dressings, medical liquids, and powder fillings. This article delves into the exceptional capabilities and commitments of Strukmyer, outlining its contributions to the medical industry.
A Comprehensive Overview of Products Manufactured at Strukmyer - an FDA-Approved, ISO-Certified Pharmaceutical Manufacturing Company based in the USA
Strukmyer has been a pioneering and reliable contract-based medical manufacturing company in the USA for years now. Their commitment to manufacturing and delivering quality-driven medical products has been attested by their adherence to FDA compliance and ISO certifications. Below is a detailed product portfolio of Strukmyer- providing a testament to their dedication to improving general patient care and well-being.
In healthcare, the treatment of wounds is a critical aspect and it can greatly impact a patient's well-being. At Strukmyer, we specialize in producing a comprehensive range of advanced wound care products with utmost care, each playing a crucial role in healthcare industries. Let's explore these innovative solutions and their importance in healthcare.
Precision and efficacy are paramount for pharmaceutical fillings. These often-overlooked medical components form the foundation of various dosage forms, ensuring that medications are accurately dosed, easily administered, and safely delivered to patients. Let's look into what pharmaceutical fillings are, how they are manufactured, and their profound importance in the healthcare industry.
Strukmyer, with its ISO certification, FDA approval, and commitment to producing the best contract-based medical products, stands as a beacon of excellence in the field of surgical collagen manufacturing. Their products not only meet but exceed industry standards, making them a preferred choice for pharmaceutical retailers and healthcare industries.